diff --git a/src/go/internal/gcimporter/gcimporter_test.go b/src/go/internal/gcimporter/gcimporter_test.go
index 9f4345d8f9..478534daf2 100644
--- a/src/go/internal/gcimporter/gcimporter_test.go
+++ b/src/go/internal/gcimporter/gcimporter_test.go
@@ -167,6 +167,8 @@ func TestImportTypeparamTests(t *testing.T) {
 	skip := map[string]string{
 		"equal.go":  "inconsistent embedded sorting", // TODO(rfindley): investigate this.
 		"nested.go": "fails to compile",              // TODO(rfindley): investigate this.
+
+		"issue46461.go": "known issue with type parameter constraints referring back to parameterized type",
 	}
 
 	for _, entry := range list {
diff --git a/test/run.go b/test/run.go
index 790b54bfd2..d2b7b88768 100644
--- a/test/run.go
+++ b/test/run.go
@@ -2188,6 +2188,8 @@ var g3Failures = setOf(
 
 	"typeparam/nested.go", // -G=3 doesn't support function-local types with generics
 
+	"typeparam/issue46461b.go", // -G=3 fails when type parameters refer back to the parameterized type itself
+
 	"typeparam/mdempsky/4.go", // -G=3 can't export functions with labeled breaks in loops
 )
 
diff --git a/test/typeparam/issue46461.go b/test/typeparam/issue46461.go
new file mode 100644
index 0000000000..2c54a6ba28
--- /dev/null
+++ b/test/typeparam/issue46461.go
@@ -0,0 +1,13 @@
+// compile -G=3
+
+// Copyright 2021 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package p
+
+type T[U interface{ M() T[U] }] int
+
+type X int
+
+func (X) M() T[X] { return 0 }
diff --git a/test/typeparam/issue46461b.dir/a.go b/test/typeparam/issue46461b.dir/a.go
new file mode 100644
index 0000000000..0d53b3e204
--- /dev/null
+++ b/test/typeparam/issue46461b.dir/a.go
@@ -0,0 +1,7 @@
+// Copyright 2021 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package a
+
+type T[U interface{ M() T[U] }] int
diff --git a/test/typeparam/issue46461b.dir/b.go b/test/typeparam/issue46461b.dir/b.go
new file mode 100644
index 0000000000..3393a375c2
--- /dev/null
+++ b/test/typeparam/issue46461b.dir/b.go
@@ -0,0 +1,11 @@
+// Copyright 2021 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package b
+
+import "./a"
+
+type X int
+
+func (X) M() a.T[X] { return 0 }
diff --git a/test/typeparam/issue46461b.go b/test/typeparam/issue46461b.go
new file mode 100644
index 0000000000..87b4ff46c1
--- /dev/null
+++ b/test/typeparam/issue46461b.go
@@ -0,0 +1,7 @@
+// compiledir -G=3
+
+// Copyright 2021 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package ignored