diff --git a/misc/cgo/testplugin/plugin_test.go b/misc/cgo/testplugin/plugin_test.go
index 28a8c669c0..a6accc1dfb 100644
--- a/misc/cgo/testplugin/plugin_test.go
+++ b/misc/cgo/testplugin/plugin_test.go
@@ -263,6 +263,13 @@ func TestIssue25756(t *testing.T) {
 	}
 }
 
+// Test with main using -buildmode=pie with plugin for issue #43228
+func TestIssue25756pie(t *testing.T) {
+	goCmd(t, "build", "-buildmode=plugin", "-o", "life.so", "./issue25756/plugin")
+	goCmd(t, "build", "-buildmode=pie", "-o", "issue25756pie.exe", "./issue25756/main.go")
+	run(t, "./issue25756pie.exe")
+}
+
 func TestMethod(t *testing.T) {
 	// Exported symbol's method must be live.
 	goCmd(t, "build", "-buildmode=plugin", "-o", "plugin.so", "./method/plugin.go")
diff --git a/src/runtime/cgo/asm_ppc64x.s b/src/runtime/cgo/asm_ppc64x.s
index 9dec8d04ce..187b2d42f6 100644
--- a/src/runtime/cgo/asm_ppc64x.s
+++ b/src/runtime/cgo/asm_ppc64x.s
@@ -12,17 +12,20 @@
 // func crosscall2(fn, a unsafe.Pointer, n int32, ctxt uintptr)
 // Saves C callee-saved registers and calls cgocallback with three arguments.
 // fn is the PC of a func(a unsafe.Pointer) function.
+// The value of R2 is saved on the new stack frame, and not
+// the caller's frame due to issue #43228.
 TEXT crosscall2(SB),NOSPLIT|NOFRAME,$0
 	// Start with standard C stack frame layout and linkage
 	MOVD	LR, R0
 	MOVD	R0, 16(R1)	// Save LR in caller's frame
 	MOVW	CR, R0		// Save CR in caller's frame
-	MOVD	R0, 8(R1)
-	MOVD	R2, 24(R1)	// Save TOC in caller's frame
+	MOVW	R0, 8(R1)
 
 	BL	saveregs2<>(SB)
 
 	MOVDU	R1, (-288-3*8-FIXED_FRAME)(R1)
+	// Save the caller's R2
+	MOVD	R2, 24(R1)
 
 	// Initialize Go ABI environment
 	BL	runtime·reginit(SB)
@@ -41,12 +44,13 @@ TEXT crosscall2(SB),NOSPLIT|NOFRAME,$0
 	MOVD	R6, FIXED_FRAME+16(R1)	// ctxt uintptr
 	BL	runtime·cgocallback(SB)
 
+	// Restore the caller's R2
+	MOVD	24(R1), R2
 	ADD	$(288+3*8+FIXED_FRAME), R1
 
 	BL	restoreregs2<>(SB)
 
-	MOVD	24(R1), R2
-	MOVD	8(R1), R0
+	MOVW	8(R1), R0
 	MOVFL	R0, $0xff
 	MOVD	16(R1), R0
 	MOVD	R0, LR