diff --git a/src/reflect/type.go b/src/reflect/type.go
index 2bb2438381..0896949d7e 100644
--- a/src/reflect/type.go
+++ b/src/reflect/type.go
@@ -2606,7 +2606,7 @@ func StructOf(fields []StructField) Type {
 				}
 			}
 		}
-		if _, dup := fset[name]; dup {
+		if _, dup := fset[name]; dup && name != "_" {
 			panic("reflect.StructOf: duplicate field " + name)
 		}
 		fset[name] = struct{}{}
diff --git a/test/fixedbugs/issue49110.go b/test/fixedbugs/issue49110.go
new file mode 100644
index 0000000000..5e1bde9f00
--- /dev/null
+++ b/test/fixedbugs/issue49110.go
@@ -0,0 +1,16 @@
+// run
+
+// Copyright 2021 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package main
+
+import "reflect"
+
+func main() {
+	_ = reflect.StructOf([]reflect.StructField{
+		{Name: "_", PkgPath: "main", Type: reflect.TypeOf(int(0))},
+		{Name: "_", PkgPath: "main", Type: reflect.TypeOf(int(0))},
+	})
+}