diff --git a/src/video/windows/SDL_windowsevents.c b/src/video/windows/SDL_windowsevents.c
index ad55c6711f..58fafd38e5 100644
--- a/src/video/windows/SDL_windowsevents.c
+++ b/src/video/windows/SDL_windowsevents.c
@@ -701,6 +701,10 @@ static void WIN_HandleRawMouseInput(Uint64 timestamp, SDL_VideoData *data, HANDL
             float fAmount = (float)amount / WHEEL_DELTA;
             SDL_SendMouseWheel(WIN_GetEventTimestamp(), window, mouseID, fAmount, 0.0f, SDL_MOUSEWHEEL_NORMAL);
         }
+
+        /* Invalidate the mouse button flags. If we don't do this then disabling raw input
+           will cause held down mouse buttons to persist when released. */
+        windowdata->mouse_button_flags = (WPARAM)-1;
     }
 }
 
diff --git a/src/video/windows/SDL_windowsgameinput.cpp b/src/video/windows/SDL_windowsgameinput.cpp
index 084b93c34e..265cb6dd25 100644
--- a/src/video/windows/SDL_windowsgameinput.cpp
+++ b/src/video/windows/SDL_windowsgameinput.cpp
@@ -279,6 +279,9 @@ static void GAMEINPUT_InitialMouseReading(WIN_GameInputData *data, SDL_Window *w
             bool down = ((state.buttons & mask) != 0);
             SDL_SendMouseButton(timestamp, window, mouseID, GAMEINPUT_button_map[i], down);
         }
+
+        // Invalidate mouse button flags
+        window->internal->mouse_button_flags = (WPARAM)-1;
     }
 }
 
@@ -308,6 +311,9 @@ static void GAMEINPUT_HandleMouseDelta(WIN_GameInputData *data, SDL_Window *wind
                     SDL_SendMouseButton(timestamp, window, mouseID, GAMEINPUT_button_map[i], down);
                 }
             }
+
+            // Invalidate mouse button flags
+            window->internal->mouse_button_flags = (WPARAM)-1;
         }
         if (delta.wheelX || delta.wheelY) {
             float fAmountX = (float)delta.wheelX / WHEEL_DELTA;